Anton E S, Kreidberg J A, Rakic P
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510-8001, USA.
Neuron. 1999 Feb;22(2):277-89. doi: 10.1016/s0896-6273(00)81089-2.
Changes in specific cell-cell recognition and adhesion interactions between neurons and radial glial cells regulate neuronal migration as well as the establishment of distinct layers in the developing cerebral cortex. Here, we show that alpha3beta1 integrin is necessary for neuron-glial recognition during neuronal migration and that alpha(v) integrins provide optimal levels of the basic neuron-glial adhesion needed to maintain neuronal migration on radial glial fibers. A gliophilic-to-neurophilic switch in the adhesive preference of developing cortical neurons occurs following the loss of alpha3beta1 integrin function. Furthermore, the targeted mutation of the alpha3 integrin gene results in abnormal layering of the cerebral cortex. These results suggest that alpha3beta1 and alpha(v) integrins regulate distinct aspects of neuronal migration and neuron-glial interactions during corticogenesis.
神经元与放射状胶质细胞之间特定的细胞间识别和黏附相互作用的变化，调节着神经元迁移以及发育中的大脑皮质中不同层的形成。在此，我们表明α3β1整合素在神经元迁移过程中对于神经元-胶质细胞识别是必需的，并且α(v)整合素为维持神经元在放射状胶质纤维上迁移所需的基本神经元-胶质细胞黏附提供了最佳水平。在α3β1整合素功能丧失后，发育中的皮质神经元的黏附偏好会发生从亲胶质细胞到亲神经元的转变。此外，α3整合素基因的靶向突变会导致大脑皮质分层异常。这些结果表明，α3β1和α(v)整合素在皮质发生过程中调节神经元迁移和神经元-胶质细胞相互作用的不同方面。
