放射状胶质细胞而非迁移神经元中的β1整合素对大脑皮质细胞层的形成至关重要。
Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex.
作者信息
Belvindrah Richard, Graus-Porta Diana, Goebbels Sandra, Nave Klaus-Armin, Müller Ulrich
机构信息
Department of Cell Biology, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
J Neurosci. 2007 Dec 12;27(50):13854-65. doi: 10.1523/JNEUROSCI.4494-07.2007.
Abstract
Radial glial cells in the cerebral cortex serve as progenitors for neurons and glia and guide the migration of cortical neurons. The integrin alpha3beta1 is thought to mediate interactions of migrating neurons with radial glial cells and to function as a receptor for the reelin signaling molecule. Here, we challenge this view and demonstrate that beta1 integrins in migrating neurons are not essential for the formation of cell layers in the cerebral cortex. Cortical cell layers also form normally in mice deficient in the integrin alpha3beta1. However, we provide evidence that beta1 integrins in radial glia control the morphological differentiation of both glia and neurons. We conclude that beta1 integrins in radial glia are required for the proper development of the cerebral cortex, whereas beta1 integrins in migrating neurons are not essential for glial-guided migration and reelin signaling.
摘要
大脑皮层中的放射状胶质细胞作为神经元和神经胶质细胞的祖细胞，并引导皮层神经元的迁移。整合素α3β1被认为介导迁移神经元与放射状胶质细胞的相互作用，并作为Reelin信号分子的受体发挥作用。在这里，我们对这一观点提出质疑，并证明迁移神经元中的β1整合素对于大脑皮层细胞层的形成并非必不可少。在缺乏整合素α3β1的小鼠中，皮层细胞层也能正常形成。然而，我们提供的证据表明，放射状胶质细胞中的β1整合素控制着神经胶质细胞和神经元的形态分化。我们得出结论，放射状胶质细胞中的β1整合素是大脑皮层正常发育所必需的，而迁移神经元中的β1整合素对于胶质细胞引导的迁移和Reelin信号传导并非必不可少。
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