Tefferi A
Division of Hematology and Internal Medicine, Mayo Clinic Rochester, Minnesota 55905, USA.
Mayo Clin Proc. 1999 Feb;74(2):159-62. doi: 10.4065/74.2.159.
The primary objective during the evaluation of erythrocytosis is to ascertain the presence or absence of polycythemia vera (PV). Because of prognostic and treatment differences, PV must be distinguished from relative polycythemia and secondary erythrocytosis. This distinction is currently accomplished through the laboratory measurement of red blood cell mass, plasma volume, and arterial oxygen saturation and determination of oxygen pressure at 50% hemoglobin saturation (P50). Furthermore, according to the Polycythemia Vera Study Group guidelines, the demonstration of an increased red blood cell mass is an absolute criterion for the diagnosis of PV. This article discusses the use of the serum erythropoietin level and endogenous erythroid colony assay as a potential alternative in the diagnosis of PV.
评估红细胞增多症的主要目的是确定真性红细胞增多症（PV）是否存在。由于预后和治疗存在差异，必须将PV与相对性红细胞增多症和继发性红细胞增多症区分开来。目前，这种区分是通过实验室测量红细胞容量、血浆容量、动脉血氧饱和度以及测定血红蛋白饱和度为50%时的氧分压（P50）来完成的。此外，根据真性红细胞增多症研究组的指南，红细胞容量增加是诊断PV的绝对标准。本文讨论了血清促红细胞生成素水平和内源性红系集落测定作为PV诊断潜在替代方法的应用。
