Tsang P C, Samaranayake L P
Faculty of Dentistry, University of Hong Kong, Hong Kong.
J Oral Pathol Med. 1999 Mar;28(3):122-7. doi: 10.1111/j.1600-0714.1999.tb02009.x.
A total of 32 HIV-infected, predominantly ethnic Chinese individuals from Hong Kong were examined for oral mucosal lesions over a period of 1 year. The commonest oral lesion found was minor aphthous ulceration (27.4%), while xerostomia (17.8%), ulceration NOS (not otherwise specified; 12.3%), hairy leukoplakia (11.0%) and erythematous candidiasis (6.9%) were less frequent; Kaposi's sarcoma was notable for its absence. When the relationship between the number of oral lesions with age, risk group, medication taken, CDC staging and CD4+ count of the study group was investigated, a significantly higher number of oral lesions was associated with use of AZT, homosexuals and CDC stage IV; in contrast, a smaller number of lesions was found in those on antiparasitics and multivitamins (all P<0.05). When compared with studies from other parts of the world, the frequency of oral lesions appeared to be less common in the current study group. However, due to a lack of similar studies from the Asian region, especially in ethnic Chinese, it is not clear whether this difference could be attributed to racial, social or geographic factors.
在1年的时间里，对32名来自香港的主要为华裔的HIV感染者进行了口腔黏膜病变检查。最常见的口腔病变是轻型阿弗他溃疡（27.4%），而口干症（17.8%）、未另作说明的溃疡（12.3%）、毛状白斑（11.0%）和红斑型念珠菌病（6.9%）则较少见；未发现卡波西肉瘤。在研究该组口腔病变数量与年龄、风险组、所服用药物、美国疾病控制与预防中心（CDC）分期及CD4 + 细胞计数之间的关系时，发现口腔病变数量显著增多与使用齐多夫定（AZT）、同性恋者及CDC IV期有关；相比之下，服用抗寄生虫药和多种维生素的人病变数量较少（所有P<0.05）。与世界其他地区的研究相比，本研究组口腔病变的发生率似乎较低。然而，由于亚洲地区尤其是华裔人群缺乏类似研究，尚不清楚这种差异是否可归因于种族、社会或地理因素。
