短期膳食补充肌酸对大鼠心肌高能磷酸盐的影响。
Effect of a short-term dietary creatine supplementation on high-energy phosphates in the rat myocardium.
作者信息
Brzezińska Z, Nazar K, Kaciuba-Uściłko H, Falecka-Wieczorek I, Wójcik-Ziółkowska E
机构信息
Department of Applied Physiology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
出版信息
J Physiol Pharmacol. 1998 Dec;49(4):591-5.
The aim of this study was to find out whether creatine (Cr) feeding affects total creatine (TCr), phosphocreatine (PCr), adenine nucleotide contents and beta-hydroxy-acyl-CoA-dehydrogenase (HAD) activity in myocardium as compared to red skeletal muscle. Ten adult Wistar rats received Cr (2.5% of diet weight) for 7 days. In Cr fed rats, PCr was increased (by approx. 20%) in cardiac and in soleus muscles with ATP elevated in myocardium and TCr and free Cr in soleus. In both muscles, Cr feeding enhanced HAD activity. It is concluded, that dietary Cr does increase cardiac muscle high energy phosphate reserves and its oxidative potential.
本研究的目的是探究与红色骨骼肌相比，补充肌酸（Cr）是否会影响心肌中的总肌酸（TCr）、磷酸肌酸（PCr）、腺嘌呤核苷酸含量以及β-羟酰基辅酶A脱氢酶（HAD）活性。十只成年Wistar大鼠接受7天的Cr（占饮食重量的2.5%）。在喂食Cr的大鼠中，心肌和比目鱼肌中的PCr增加（约20%），心肌中的ATP升高，比目鱼肌中的TCr和游离Cr升高。在这两种肌肉中，补充Cr均增强了HAD活性。得出的结论是，饮食中的Cr确实会增加心肌的高能磷酸盐储备及其氧化潜力。
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