用于肿瘤成像的正电子发射示踪剂[11C]胆碱的自动化合成。
Automated synthesis of [11C]choline, a positron-emitting tracer for tumor imaging.
作者信息
Hara T, Yuasa M
机构信息
Department of Radiology, International Medical Center of Japan, Tokyo, Japan.
出版信息
Appl Radiat Isot. 1999 Mar;50(3):531-3. doi: 10.1016/s0969-8043(98)00097-9.
(beta-Hydroxyethyl)tri([11C]methyl)ammonium ([11C]choline) is a tracer very effective in imaging various human tumors using positron emission tomography (PET). We have constructed a computer-controlled [11C]choline synthetic apparatus which carries out the whole process of synthesis and product purification automatically. The setup is simple and the process quick. In 20 min, 11 GBq of [11C]choline (chloride) is obtainable from 26 GBq of [11C]CO2. The final product is a sterile and pyrogen-free [11C]choline "injection".
（β-羟乙基）三（[¹¹C]甲基）铵（[¹¹C]胆碱）是一种在使用正电子发射断层扫描（PET）对各种人类肿瘤进行成像时非常有效的示踪剂。我们构建了一种计算机控制的[¹¹C]胆碱合成装置，该装置可自动完成合成和产物纯化的全过程。装置设置简单，过程快速。在20分钟内，可从26 GBq的[¹¹C]CO₂获得11 GBq的[¹¹C]胆碱（氯化物）。最终产品是无菌、无热原的[¹¹C]胆碱“注射液”。
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