Sauvant M P, Pepin D, Piccinni E
UFR Pharmacie, Laboratoire Hydrologie, Environnement et Santé Publique, Clermont-Ferrand, France.
Chemosphere. 1999 Mar;38(7):1631-69. doi: 10.1016/s0045-6535(98)00381-6.
Among protozoa, Tetrahymena pyriformis is the most commonly ciliated model used for laboratory research. After a brief description of the morphology and biology of Tetrahymena pyriformis, this article focuses on the most important and recent investigations performed with this species in toxicology and ecotoxicology. The methodological features of its culture, and main tests, based on cell growth rate, biochemical markers, behavioral changes and motility, are discussed. Examples of xenobiotics (organic and inorganic substances, pharmaceutical drugs, water pollutants) tested with Tetrahymena pyriformis are also given.
在原生动物中，梨形四膜虫是实验室研究中最常用的纤毛虫模型。在简要描述梨形四膜虫的形态和生物学特性之后，本文重点介绍了该物种在毒理学和生态毒理学方面最重要和最新的研究。讨论了其培养的方法学特点以及基于细胞生长速率、生化标志物、行为变化和运动性的主要测试。还给出了用梨形四膜虫测试的外源化合物（有机和无机物质、药物、水污染物）的例子。
