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轻度至中度颅脑损伤的一年预后:与主诉及重返工作相关的急性损伤特征的预测价值

One year outcome in mild to moderate head injury: the predictive value of acute injury characteristics related to complaints and return to work.

作者信息

van der Naalt J, van Zomeren A H, Sluiter W J, Minderhoud J M

机构信息

Department of Neurology, University Hospital Groningen, The Netherlands.

出版信息

J Neurol Neurosurg Psychiatry. 1999 Feb;66(2):207-13. doi: 10.1136/jnnp.66.2.207.

Abstract

OBJECTIVES

To determine the prognostic value of characteristics of acute injury and duration of post-traumatic amnesia (PTA) for long term outcome in patients with mild to moderate head injury in terms of complaints and return to work.

METHODS

Patients with a Glasgow coma score (GCS) on admission of 9-14 were included. Post-traumatic amnesia was assessed prospectively. Follow up was performed at 1, 3, 6, and 12 months after injury. Outcome was determined by the Glasgow outcome scale (GOS) 1 year after injury and compared with a more detailed outcome scale (DOS) comprising cognitive and neurobehavioural aspects.

RESULTS

Sixty seven patients were included, mean age 33.2 (SD 14.7) years and mean PTA 7.8 (SD 7.3) days. One year after injury, 73% of patients had resumed previous work although most (84%) still reported complaints. The most frequent complaints were headache (32%), irritability (34%), forgetfulness and poor concentration (42%), and fatigue (45%). According to the GOS good recovery (82%) or moderate disability (18%) was seen. Application of the DOS showed more cognitive (40%) and behavioural problems (48%), interfering with return to work. Correlation between the GOS and DOS was high (r=0.87, p<0.01). Outcome correlated with duration of PTA (r=-0.46) but not significantly with GCS on admission (r=0.19). In multiple regression analysis, PTA and the number of complaints 3 months after injury explained 49% of variance on outcome as assessed with the GOS, and 60% with the DOS.

CONCLUSIONS

In mild to moderate head injury outcome is determined by duration of PTA and not by GCS on admission. Most patients return to work despite having complaints. The application of a more detailed outcome scale will increase accuracy in predicting outcome in this category of patients with head injury.

摘要

目的

就症状及重返工作情况而言,确定急性损伤特征及创伤后遗忘(PTA)持续时间对轻至中度颅脑损伤患者长期预后的预测价值。

方法

纳入入院时格拉斯哥昏迷评分(GCS)为9 - 14分的患者。对创伤后遗忘进行前瞻性评估。在受伤后1、3、6和12个月进行随访。伤后1年通过格拉斯哥预后量表(GOS)确定预后,并与包含认知和神经行为方面的更详细预后量表(DOS)进行比较。

结果

纳入67例患者,平均年龄33.2(标准差14.7)岁,平均PTA为7.8(标准差7.3)天。受伤1年后,73%的患者恢复了之前的工作,尽管大多数(84%)仍有症状。最常见的症状是头痛(32%)、易怒(34%)、健忘和注意力不集中(42%)以及疲劳(45%)。根据GOS,可见良好恢复(82%)或中度残疾(18%)。DOS的应用显示更多认知(40%)和行为问题(48%),影响重返工作。GOS与DOS之间的相关性很高(r = 0.87,p < 0.01)。预后与PTA持续时间相关(r = -0.46),但与入院时的GCS无显著相关性(r = 0.19)。在多元回归分析中,PTA及受伤3个月后的症状数量解释了GOS评估的预后方差的49%,以及DOS评估的60%。

结论

在轻至中度颅脑损伤中,预后由PTA持续时间决定,而非入院时的GCS。大多数患者尽管有症状仍能重返工作。应用更详细的预后量表将提高预测此类颅脑损伤患者预后的准确性。

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