P57（KIP2）基因多态性与乳腺癌风险

P57 (KIP2) polymorphisms and breast cancer risk.

作者信息

Li Y, Millikan R C, Newman B, Conway K, Tse C K, Liu E T

机构信息

Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7400, USA.

出版信息

Hum Genet. 1999 Jan;104(1):83-8. doi: 10.1007/s004390050914.

DOI:10.1007/s004390050914

PMID:10071197

Abstract

A previous report in this journal has suggested that germline deletions in the proline-alanine-rich (PAPA-repeat) region of P57 (KIP2) are associated with increased risk of a variety of cancers, including breast cancer. We have analyzed the association of P57 PAPA-repeat deletion polymorphisms and breast cancer risk as part of a population-based case-control study of breast cancer. We have not observed an association between the presence of one or two copies of deletion polymorphisms in P57 and breast cancer risk (adjusted odds ratio: 1.1, 95% confidence interval: 0.6-2.0). Further investigation is necessary to determine the functional significance of P57 deletion polymorphisms and their potential relationship with disease.

摘要

本杂志之前的一篇报道表明，P57（KIP2）富含脯氨酸 - 丙氨酸（PAPA重复）区域的种系缺失与包括乳腺癌在内的多种癌症风险增加有关。作为一项基于人群的乳腺癌病例对照研究的一部分，我们分析了P57 PAPA重复缺失多态性与乳腺癌风险之间的关联。我们未观察到P57中存在一个或两个缺失多态性拷贝与乳腺癌风险之间存在关联（调整后的优势比：1.1，95%置信区间：0.6 - 2.0）。有必要进行进一步研究以确定P57缺失多态性的功能意义及其与疾病的潜在关系。