Dobrev H P
Department of Dermatology, Higher Medical Institute, Plovdiv, Bulgaria.
J Am Acad Dermatol. 1999 Mar;40(3):436-42. doi: 10.1016/s0190-9622(99)70494-9.
Measurements of skin elasticity are more sensitive than the skin severity score and appropriate for evaluation of sclerodermatous skin.
Our purpose was to investigate the mechanical properties of the skin in patients with systemic sclerosis depending on the stage of the disease.
Seventeen patients, 8 with edematous phase and 9 with indurative phase of skin involvement, and 16 healthy subjects were studied. Clinical scoring of skin thickness and measurements of skin elasticity with a noninvasive suction device (Cutometer) were performed over 11 anatomic regions.
Edematous phase was characterized by significantly lower immediate distention (Ue) and final distention (Uf), and higher viscoelastic to elastic ratio (Uv/Ue) of the skin compared with indurative phase, except for the forehead (8 mm probe). The changes in skin mechanical parameters for fingers were identical in both phases. Low values of skin distensibility correlated with severe skin thickness or hidebound skin. Results were influenced by body site and by the diameter of measuring probe used.
The noninvasive method applied is suitable for objective and quantitative monitoring of skin involvement in patients with systemic sclerosis.
皮肤弹性测量比皮肤严重程度评分更敏感，适用于硬皮病皮肤的评估。
我们的目的是根据疾病阶段研究系统性硬化症患者皮肤的力学特性。
研究了17例患者，其中8例处于皮肤受累的水肿期，9例处于硬结期，以及16名健康受试者。在11个解剖区域进行了皮肤厚度的临床评分和使用无创吸力装置（皮肤弹性测定仪）测量皮肤弹性。
与硬结期相比，除额头（8毫米探头）外，水肿期的特点是皮肤的即时扩张度（Ue）和最终扩张度（Uf）显著降低，粘弹性与弹性比值（Uv/Ue）更高。两个阶段手指的皮肤力学参数变化相同。皮肤伸展性低值与严重的皮肤厚度或紧绷皮肤相关。结果受身体部位和所用测量探头直径的影响。
所应用的无创方法适用于客观、定量监测系统性硬化症患者的皮肤受累情况。
