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与健康对照组相比,用Cutometer MPA 580测量的轻度杜普伊特伦挛缩病患者手掌皮肤弹性降低。

Palmar skin elasticity measured by the Cutometer MPA 580 is decreased in mild Dupuytren's disease compared to healthy controls.

作者信息

Van Nuffel Maarten, Meulyzer Caroline, Gheysen Britt, Böhrer Arne, Anthonissen Mieke, Van den Kerckhove Eric, Degreef Ilse

机构信息

Department of Medical Sciences, KU Leuven-University of Leuven; Hand Unit, Department of Orthopaedic Surgery, University Hospitals Leuven, Leuven, Belgium.

Department of Rehabilitation Sciences, KU Leuven-University of Leuven; Department of Physical Medicine and Rehabilitation, University Hospitals Leuven, Leuven, Belgium.

出版信息

Hand Ther. 2022 Mar;27(1):14-21. doi: 10.1177/17589983211061616. Epub 2022 Jan 18.

Abstract

INTRODUCTION

Involvement of the palmar skin is often seen in patients with Dupuytren's disease (DD) with severe finger contractures. However, skin elasticity may be already decreased earlier in the disease. The Cutometer MPA 580 could provide an objective skin measurement tool to assess this decrease in elasticity. Linking objective skin measurements to functional outcome measures could lead to better prediction of disease progression. We set up a study to investigate if the Cutometer was able to detect differences in skin elasticity between patients with mild Dupuytren's disease and healthy controls.

METHODS

A cross-sectional analytical study was performed. Three assessors measured skin elasticity (palmar hand) on two sites using the Cutometer on 30 patients with mild DD and 30 healthy controls. Student's -test was used to evaluate differences in skin elasticity and a linear model to evaluate interactions between the groups and sites.

RESULTS

Significant differences in skin elasticity were found between DD patients and controls, as well as differences based on the location examined.

DISCUSSION

Similar to other skin conditions, the Cutometer MPA 580 was able to demonstrate a significant lower elasticity in the palmar skin in DD patients compared to healthy controls. A decrease in skin elasticity in different locations of the hand correlated with areas that often pose problems in the treatment of more severe DD. The Cutometer could potentially be a tool to identify these areas earlier in the disease.

摘要

引言

掌部皮肤受累在患有严重手指挛缩的杜普伊特伦挛缩病(DD)患者中很常见。然而,在疾病早期皮肤弹性可能就已经下降。Cutometer MPA 580可以提供一种客观的皮肤测量工具来评估这种弹性下降情况。将客观的皮肤测量与功能结局指标联系起来可能会更好地预测疾病进展。我们开展了一项研究,以调查Cutometer是否能够检测出轻度杜普伊特伦挛缩病患者与健康对照者之间皮肤弹性的差异。

方法

进行了一项横断面分析研究。三名评估者使用Cutometer在30例轻度DD患者和30名健康对照者的两个部位测量皮肤弹性(手掌)。采用学生t检验评估皮肤弹性差异,并使用线性模型评估组间和部位间的相互作用。

结果

发现DD患者与对照者之间的皮肤弹性存在显著差异,并且在所检查的部位上也存在差异。

讨论

与其他皮肤疾病类似,与健康对照者相比,Cutometer MPA 580能够证明DD患者掌部皮肤的弹性明显较低。手部不同部位的皮肤弹性下降与在更严重的DD治疗中经常出现问题的区域相关。Cutometer有可能成为在疾病早期识别这些区域的一种工具。

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