Duncan K O, Tigelaar R E, Bolognia J L
Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520-8059, USA.
J Am Acad Dermatol. 1999 Mar;40(3):493-6. doi: 10.1016/s0190-9622(99)70508-6.
Stevens-Johnson syndrome (SJS) is a severe cutaneous eruption that most often appears as an adverse reaction to a medication. There have been 21 reported cases of atypical erythema multiforme, toxic epidermal necrolysis, and SJS arising in patients receiving radiation therapy in addition to phenytoin, phenobarbital, or carbamazepine. We report the second case of SJS resulting from concomitant phenobarbital and radiation therapy, in which the eruption was limited to the sites of radiation, which were multiple.
史蒂文斯-约翰逊综合征（SJS）是一种严重的皮肤疹，最常表现为对药物的不良反应。除苯妥英、苯巴比妥或卡马西平外，接受放射治疗的患者中已有21例报告出现非典型多形性红斑、中毒性表皮坏死松解症和SJS。我们报告了第二例由苯巴比妥和放射治疗同时引起的SJS病例，其中皮疹仅限于多个放射部位。
