Drucker-Colín R, Verdugo-Díaz L, Morgado-Valle C, Solís-Maldonado G, Ondarza R, Boll C, Miranda G, Wang G J, Volkow N
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México, D.F.
Arch Med Res. 1999 Jan-Feb;30(1):33-9. doi: 10.1016/s0188-0128(98)00007-4.
Treatment of Parkinson's Disease (PD) has been attempted by others by transplanting either the patient's own adrenal medullary tissue or fetal substantia nigra into caudate or putamen areas. However, the difficulties inherent in using the patient's own adrenal gland, or the difficulty in obtaining human fetal tissue, has generated the need to find alternative methods.
We report here of an alternative to both procedures by using as transplant material cultured human adrenal chromaffin cells differentiated into neuron-like cells by extremely low frequency magnetic fields (ELF MF).
The results of this study show that human differentiated chromaffin cells can be grafted into the caudate nucleus of a PD patient, generating substantial clinical improvement, as measured by the Unified Rating Scale for PD, which correlated with glucose metabolism and D2 DA receptor increases as seen in a PET scan, while allowing a 70% decrease in L-Dopa medication.
This is the first preliminary report showing that transplants of cultured differentiated neuron-like cells can be successfully used to treat a PD patient.
其他人曾尝试通过将患者自身的肾上腺髓质组织或胎儿黑质移植到尾状核或壳核区域来治疗帕金森病（PD）。然而，使用患者自身肾上腺存在的固有困难，或获取人类胎儿组织的困难，促使人们需要寻找替代方法。
我们在此报告一种替代这两种手术的方法，即使用经极低频磁场（ELF MF）分化为神经元样细胞的培养人肾上腺嗜铬细胞作为移植材料。
本研究结果表明，人分化嗜铬细胞可移植到PD患者的尾状核中，产生显著的临床改善，这通过PD统一评分量表来衡量，该量表与正电子发射断层扫描（PET）中所见的葡萄糖代谢和D2多巴胺受体增加相关，同时左旋多巴药物用量减少了70%。
这是第一份初步报告，表明培养的分化神经元样细胞移植可成功用于治疗PD患者。
