Simola M, Holopainene E, Malmberg H
Department of Otorhinolaryngology, Helsinki University Central Hospital, Finland.
Ann Allergy Asthma Immunol. 1999 Feb;82(2):152-6. doi: 10.1016/S1081-1206(10)62589-6.
Allergic skin test reactivity tends to decrease with aging, but whether the decrease is associated with changes in symptom severity and duration of the disease or determined only by aging, is poorly understood.
Our aim was to analyze skin test sensitivity some 20 years after primary testing and to relate possible changes in reactivity to aging, duration of rhinitis, and changes in severity of rhinitis symptoms.
One hundred and seven rhinitis patients who had been investigated earlier were re-interviewed and their current allergy re-assessed after a follow-up of 23 years. All patients were skin prick tested with 22 to 26 common allergens. The allergic rhinitis status was verified with nasal allergen challenge.
Skin test reactivity showed a significant trend decreasing towards older age groups over the period between the two investigations. Rhinitis symptoms tended, on average, to become milder during the follow-up, but an association between skin test reactivity and changes in symptom severity could not be verified.
Rhinitis symptoms tend to become milder and the allergic skin reactivity usually decreases in the long run, but these changes may occur independently of each other. In this study, the change in rhinitis symptom severity seems not to be related to the decrease in skin test reactivity.
过敏性皮肤试验反应性往往会随着年龄增长而降低，但这种降低是与疾病症状的严重程度和持续时间的变化有关，还是仅由衰老决定，目前尚不清楚。
我们的目的是在初次检测约20年后分析皮肤试验敏感性，并将反应性的可能变化与衰老、鼻炎持续时间以及鼻炎症状严重程度的变化联系起来。
对107名先前接受过调查的鼻炎患者进行了再次访谈，并在随访23年后重新评估了他们目前的过敏情况。所有患者均用22至26种常见变应原进行皮肤点刺试验。通过鼻变应原激发试验来验证过敏性鼻炎状态。
在两次调查期间，皮肤试验反应性在老年人群中呈现出显著的下降趋势。在随访期间，鼻炎症状平均趋于减轻，但皮肤试验反应性与症状严重程度变化之间的关联无法得到证实。
从长远来看，鼻炎症状往往会减轻，过敏性皮肤反应性通常会降低，但这些变化可能彼此独立发生。在本研究中，鼻炎症状严重程度的变化似乎与皮肤试验反应性的降低无关。
