Dipartimento di Medicina Interna e Specialistica (DIMIS), Università degli Studi di Palermo, Via del Vespro, 141, 90127, Palermo, Italy.
Clin Exp Med. 2013 Feb;13(1):67-73. doi: 10.1007/s10238-012-0175-8. Epub 2012 Feb 4.
Changes in rhinitis symptom severity tend to decrease with aging, but whether the decrease is associated with allergic skin test reactivity, serum total and specific IgE, and nasal eosinophils or determined only by aging is poorly understood. The aim of the study was to analyze sensitivity in vivo and in vitro some 15 years after primary testing, skin prick test (SPT), serum total and specific IgE, ratio sIgE/tIgE, and nasal eosinophils in order to evaluate changes due to age and changes due to the severity of rhinitis symptoms. One hundred and eight rhinitis patients who had been investigated in 1995 were re-interviewed and their current allergy re-assessed after a follow-up of 15 years. All patients were SPT with eight common allergens in the area of Palermo (Italy). Rhinitis symptoms tended, on average, to have become milder at the follow-up. All parameters examined showed a decreasing trend in older age groups over the period between the two investigations. Rhinitis symptoms tend to become milder and the allergic parameters both in vivo and in vitro usually decrease in the long run; however, the changes in rhinitis symptoms appear to be related to changes in the nasal eosinophils, independently of SPT and serum-specific IgE.
变应性鼻炎症状严重程度随年龄增长而趋于减轻，但这种减轻是否与变应性皮肤试验反应性、血清总 IgE 和特异性 IgE 以及鼻嗜酸粒细胞有关，或者仅由年龄决定，尚不清楚。本研究的目的是分析在初次检测后约 15 年时体内和体外的敏感性，进行皮肤点刺试验（SPT）、血清总 IgE 和特异性 IgE、sIgE/tIgE 比值和鼻嗜酸粒细胞，以评估因年龄变化和因变应性鼻炎症状严重程度变化所致的改变。对 1995 年接受调查的 108 例变应性鼻炎患者进行重新访谈，并在随访 15 年后重新评估其当前过敏情况。所有患者均在意大利巴勒莫地区进行了 8 种常见过敏原的 SPT。在随访时，变应性鼻炎症状平均趋于减轻。在两次调查之间的这段时间里，所有检查参数在年龄较大的人群中均呈下降趋势。变应性鼻炎症状倾向于变得更轻，体内和体外的过敏参数通常会随着时间的推移而减少；然而，变应性鼻炎症状的变化似乎与鼻嗜酸粒细胞的变化有关，与 SPT 和血清特异性 IgE 无关。
