Dangas N, Parashou E, Lymberi M, Kehayas P
Department of Urology, Hippokration General Hospital, Athens, Greece.
Br J Urol. 1993 Nov;72(5 Pt 1):539-43. doi: 10.1111/j.1464-410x.1993.tb16204.x.
This experimental study was designed to investigate the responses of renal function to elevated intravesical pressure. Ten male New Zealand type rabbits were used. A supravesical ureterocutaneous urinary diversion was performed in all rabbits to disconnect bladder and kidneys and to ensure a free urine flow. Two parameters of renal function were measured simultaneously: urine output by simple collection and glomerular filtration rate (GFR) by total plasma clearance of 51Cr-EDTA. Measurements were performed initially with the bladder empty and then with intravesical pressure 60 cm H2O. A significant decrease in urine output and in GFR was observed in all rabbits when the bladder was overdistended. Urine output returned to the initial levels after relief of the increased intravesical pressure. The results suggest that for these responses a vesicorenal reflex activated by the elevated intravesical pressure is responsible.
本实验研究旨在探讨膀胱内压升高时肾功能的反应。使用了10只雄性新西兰兔。对所有兔子进行膀胱上输尿管皮肤造口尿流改道，以分离膀胱和肾脏并确保尿液自由流动。同时测量两个肾功能参数：通过简单收集尿液来测定尿量，通过51Cr-EDTA的总血浆清除率来测定肾小球滤过率（GFR）。最初在膀胱空虚时进行测量，然后在膀胱内压为60 cm H2O时进行测量。当膀胱过度扩张时，所有兔子的尿量和GFR均显著下降。膀胱内压升高解除后，尿量恢复到初始水平。结果表明，这些反应是由膀胱内压升高激活的膀胱肾反射引起的。
