Carstensen J T, Dali M
School of Pharmacy, University of Wisconsin, Madison 53706, USA.
Drug Dev Ind Pharm. 1999 Mar;25(3):347-52. doi: 10.1081/ddc-100102180.
When particle size distribution parameters are calculated from sieve analysis, it is generally assumed that the distribution within the particle cut is either linear, producing a mean particle size equal to the average of the mesh openings (1-3), or that a more proper number is the geometric mean of these two apertures. It is shown here that particles within a mesh cut are not linearly distributed, but rather may be normally, long-normally, or biphasic combinations of the two. Three compounds were examined in this fashion, and results are reported here.
当通过筛分分析计算粒度分布参数时,通常假定颗粒截面上的分布要么是线性的,得出的平均粒度等于筛孔尺寸的平均值(1 - 3),要么更合适的数值是这两个孔径的几何平均值。本文表明,筛孔截面上的颗粒并非线性分布,而是可能呈正态分布、长正态分布或二者的双相组合。以这种方式对三种化合物进行了研究,并在此报告结果。