Ballerini C, Nacmias B, Rombolà G, Marcon G, Massacesi L, Sorbi S
Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
Ann Neurol. 1999 Mar;45(3):397-400. doi: 10.1002/1531-8249(199903)45:3<397::aid-ana18>3.0.co;2-4.
The prevalence of the HLA A2 allele was investigated in a group of Italian patients with sporadic and early-onset familial Alzheimer's disease (AD and FAD) to analyze the potential association of this allele with early age of onset of the disease. The possible interaction between the HLA A2 allele and apolipoprotein E epsilon4 allele was analyzed. Our data suggest that A2 and epsilon4 alleles may have additive effects on AD onset, and that A2 may play an important role in determining or contributing to a very early age at onset. These findings further support the hypothesis of the involvement of an immune/inflammatory mechanism in the pathogenesis of AD.
对一组患有散发性和早发性家族性阿尔茨海默病（AD和FAD）的意大利患者进行了HLA A2等位基因流行率的调查，以分析该等位基因与疾病早发之间的潜在关联。分析了HLA A2等位基因与载脂蛋白Eε4等位基因之间可能的相互作用。我们的数据表明，A2和ε4等位基因可能对AD发病具有累加效应，并且A2可能在决定或促成非常早的发病年龄方面发挥重要作用。这些发现进一步支持了免疫/炎症机制参与AD发病机制的假说。
