Araria-Goumidi L, Lambert J C, Cottel D, Amouyel P, Chartier-Harlin M C
INSERM U 508, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Cédex, Lille, France.
Neurosci Lett. 2002 Dec 25;335(2):75-8. doi: 10.1016/s0304-3940(02)01057-1.
A possible association of the human leucocyte antigen (HLA)-A2 allele with increased susceptibility to Alzheimer's disease (AD) has been the subject of debate for more than 20 years. We compared the presence of the HLA-A2 allele in a sample from the French population composed of 451 patients and 477 controls. There was no evidence of an association of this allele with increased risk of AD. Moreover, no effect was observed when we stratified the case-control sample on gender, age of onset or presence of an APOE epsilon4 allele. We conclude that HLA-A2 allele is not a major risk factor for sporadic AD.
人类白细胞抗原（HLA）-A2等位基因与阿尔茨海默病（AD）易感性增加之间可能存在的关联，二十多年来一直是争论的焦点。我们比较了来自法国人群的一个样本（由451例患者和477名对照组成）中HLA-A2等位基因的情况。没有证据表明该等位基因与AD风险增加有关。此外，当我们按性别、发病年龄或APOE ε4等位基因的存在情况对病例对照样本进行分层时，未观察到任何影响。我们得出结论，HLA-A2等位基因不是散发性AD的主要危险因素。
