Kashyap R, Choudhry V P, Pati H P
Department of Hematology, All India Institute of Medical Sciences, New Delhi.
Am J Hematol. 1999 Mar;60(3):225-8. doi: 10.1002/(sici)1096-8652(199903)60:3<225::aid-ajh10>3.0.co;2-s.
Cyclic acquired amegakaryocytic thrombocytopenic purpura (AATP) is a rare disorder characterized by periodic fluctuations in the platelet counts due to a defect in the platelet production. We describe a 42-year-old female with cyclic AATP, in whom the cyclic fluctuations in the platelet counts ceased with danazol therapy. The pathogenesis of the disease and the possible mechanisms of danazol action have been reviewed.
周期性获得性无巨核细胞性血小板减少性紫癜（AATP）是一种罕见的疾病，其特征是由于血小板生成缺陷导致血小板计数出现周期性波动。我们描述了一名患有周期性AATP的42岁女性，她的血小板计数周期性波动在达那唑治疗后停止。本文对该疾病的发病机制以及达那唑作用的可能机制进行了综述。
