Ryu S, Jimi S, Eura Y, Kato T, Takebayashi S
The Second Department of Pathology, School of Medicine, Fukuoka University, Japan.
Cancer Lett. 1998 Nov 27;133(2):215-22. doi: 10.1016/s0304-3835(98)00260-2.
We previously showed that thyroid carcinoma distinctively expresses intracellular fibronectin (FN) compared to other carcinomas. To determine the persistency of such FN accumulation in metastasis, we immunohistochemically examined the accumulation of intracellular FN in 92 cases of different carcinomas originating from the thyroid gland, lung and kidney, 44 of which showed metastasis to other organs. In all of the cases, normal epithelial cells adjacent to carcinomas did not show intracellular FN. Almost all of the cases (31/32) of thyroid carcinoma with/without metastasis to the lung and/or kidney showed intracellular FN in both the primary and metastatic lesions. Few cases (2/38) of lung carcinoma and none of the 22 cases of kidney carcinoma showed intracellular FN in the primary and metastatic lesions. In conclusion, the intracellular accumulation of FN acquired after carcinogenic transformation is not a common phenomenon in carcinomas, but rather is distinctive for thyroid carcinoma, even when it metastasizes to other organs. The immunohistochemical detection of intracellular FN may be useful for diagnosing thyroid carcinoma, even in metastatic lesions.
我们之前的研究表明，与其他癌症相比，甲状腺癌独特地表达细胞内纤连蛋白（FN）。为了确定这种FN积累在转移过程中的持续性，我们采用免疫组织化学方法检测了92例源自甲状腺、肺和肾的不同癌症中细胞内FN的积累情况，其中44例出现了向其他器官的转移。在所有病例中，癌旁的正常上皮细胞均未显示细胞内FN。几乎所有（31/32）伴有或不伴有肺和/或肾转移的甲状腺癌病例，其原发灶和转移灶均显示细胞内FN。肺癌病例中仅有少数（2/38）在原发灶和转移灶显示细胞内FN，而22例肾癌病例中无一例在原发灶和转移灶显示细胞内FN。总之，致癌转化后获得的FN细胞内积累在癌症中并非常见现象，而是甲状腺癌所特有的，即使其转移至其他器官也是如此。细胞内FN的免疫组织化学检测可能有助于甲状腺癌的诊断，即使在转移灶中也是如此。
