Ryu S, Jimi S, Takebayashi S
The Second Department of Pathology, School of Medicine, Fukuoka University, Japan.
Cancer Lett. 1997 Dec 23;121(2):189-93. doi: 10.1016/s0304-3835(97)00353-4.
Fibronectin is a multifunctional protein that plays a role in tumor invasion. We immunohistochemically examined the in vivo expression of fibronectin in thyroid carcinoma in comparison with other carcinomas, such as hepatocellular carcinoma, transitional cell carcinoma and gastric adenocarcinoma. Intracellular localization of fibronectin was found in almost all cases of thyroid carcinoma. In contrast, hepatocellular carcinoma showed a lower expression rate and the other carcinomas were all negative. These results indicate that the intracellular expression of fibronectin is not a common phenomenon in carcinoma, but rather is distinctive for thyroid carcinoma.
纤连蛋白是一种多功能蛋白，在肿瘤侵袭中发挥作用。我们采用免疫组织化学方法检测了甲状腺癌中纤连蛋白的体内表达情况，并与其他癌症（如肝细胞癌、移行细胞癌和胃腺癌）进行了比较。几乎所有甲状腺癌病例均发现纤连蛋白的细胞内定位。相比之下，肝细胞癌的表达率较低，而其他癌症均为阴性。这些结果表明，纤连蛋白的细胞内表达在癌症中并非常见现象，而是甲状腺癌所特有的。
