[Experimental morphological study of the vaccination process following aerosol application of lyophilized live influenza A2/Hong Kong and B/USSR vaccines].

A comparative study of immunologic, immunomorphological and morphological responses of the viscera of white rats immunized by aerosol intranasally with lyophilized influenza A2/Hong Kong and B/USSR vaccines with an adjuvant (typhoid antigen) and without it was carried out. Also lung tissues were examined for intracellular inclusions considered to be a morphological indication of influenza virus implantation. No pathological lesions were found in the organs of the immunized animals. It is concluded that the intensity of immunologic and immuno-morphological responses depends upon the method of vaccine application and upon vaccine type but not upon the adjuvant.