Kouzarides T
Wellcome/CRC Institute, Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, UK.
Curr Opin Genet Dev. 1999 Feb;9(1):40-8. doi: 10.1016/s0959-437x(99)80006-9.
There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals their involvement in cell-cycle regulation and differentiation. Furthermore, accumulating evidence suggests that deregulation of acetylase and deacetylase activity plays a causative role in the generation of cancer.
有几种酶，即乙酰化酶和去乙酰化酶，它们可以通过改变组蛋白或其他与启动子结合的转录因子的乙酰化状态来调节转录。其中一些酶存在于多亚基复合物中。最近为了解这些酶的生物学作用所做的努力揭示了它们参与细胞周期调控和分化。此外，越来越多的证据表明，乙酰化酶和去乙酰化酶活性的失调在癌症的发生中起因果作用。
