Amon A
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
Curr Opin Genet Dev. 1999 Feb;9(1):69-75. doi: 10.1016/s0959-437x(99)80010-0.
Prior to sister-chromatid separation, the spindle checkpoint inhibits cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules. Recent work has shown that the spindle checkpoint inhibits cell-cycle progression by direct binding of components of the spindle checkpoint pathway to components of a specialized ubiquitin-conjugating system that is responsible for triggering sister-chromatid separation.
在姐妹染色单体分离之前，纺锤体检查点会响应有丝分裂纺锤体损伤或未附着于微管的染色体产生的信号，抑制细胞周期进程。最近的研究表明，纺锤体检查点通过纺锤体检查点途径的组分直接结合到负责触发姐妹染色单体分离的特殊泛素偶联系统的组分上，从而抑制细胞周期进程。
