Burke Daniel J, Stukenberg P Todd
Department of Biochemistry and Molecular Genetics, University of Virginia Medical Center, 1300 Jefferson Park Avenue, Box 800733, Charlottesville, VA 22908-0733, USA.
Dev Cell. 2008 Apr;14(4):474-9. doi: 10.1016/j.devcel.2008.03.015.
The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle. Popular models propose that checkpoint proteins associate with kinetochores to produce a "wait anaphase" signal that inhibits anaphase. Recent data suggest that a two-state switch results from using the same kinetochore proteins to bind microtubules and checkpoint proteins. At least eight protein kinases are implicated in spindle checkpoint signaling, arguing that a traditional signal transduction cascade is integral to spindle checkpoint signaling.
纺锤体检查点会阻止细胞周期进程,直到染色体正确地附着于有丝分裂纺锤体上。流行的模型提出,检查点蛋白与动粒结合以产生一个“等待后期”信号,该信号会抑制后期。最近的数据表明,使用相同的动粒蛋白结合微管和检查点蛋白会导致一种双态转换。至少有八种蛋白激酶与纺锤体检查点信号传导有关,这表明传统的信号转导级联对于纺锤体检查点信号传导不可或缺。