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Strategies for improving responses to DNA vaccines.

作者信息

Boyle J S, Barr I G, Lew A M

机构信息

Co-operative Research Centre for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, 3050.

出版信息

Mol Med. 1999 Jan;5(1):1-8. doi: 10.1007/s008940050100.

DOI:10.1007/s008940050100
PMID:10072442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2230370/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/2230370/9047ea714b83/molmed00001-0011-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/2230370/b74d5c7dc0c7/molmed00001-0009-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/2230370/9047ea714b83/molmed00001-0011-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/2230370/b74d5c7dc0c7/molmed00001-0009-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/2230370/9047ea714b83/molmed00001-0011-a.jpg

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Immunization with the gene expressing woodchuck hepatitis virus nucleocapsid protein fused to cytotoxic-T-lymphocyte-associated antigen 4 leads to enhanced specific immune responses in mice and woodchucks.用表达与细胞毒性T淋巴细胞相关抗原4融合的土拨鼠肝炎病毒核衣壳蛋白的基因进行免疫，可增强小鼠和土拨鼠的特异性免疫反应。
J Virol. 2005 May;79(10):6368-76. doi: 10.1128/JVI.79.10.6368-6376.2005.
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Nucleic acid vaccines: tasks and tactics.核酸疫苗：任务与策略。
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A fusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge.

本文引用的文献

1
Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.一种疟疾DNA疫苗在人体内诱导抗原特异性细胞毒性T淋巴细胞的产生。
Science. 1998 Oct 16;282(5388):476-80. doi: 10.1126/science.282.5388.476.
2
First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response.用于治疗1型人类免疫缺陷病毒感染的DNA疫苗首次人体试验：安全性和宿主反应
J Infect Dis. 1998 Jul;178(1):92-100. doi: 10.1086/515613.
3
Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients.
一种靶向抗原呈递细胞的融合DNA疫苗可增强对病毒攻击的保护作用。
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6676-80. doi: 10.1073/pnas.120162497.
DNA疫苗接种在HIV-1感染患者中诱导的细胞毒性反应。
Lancet. 1998 May 2;351(9112):1320-5. doi: 10.1016/S0140-6736(97)09440-3.
4
Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/antigen-presenting cells.通过体内转染及巨噬细胞/抗原呈递细胞的激活，基于DNA免疫后的特异性免疫诱导。
J Immunol. 1998 Jun 15;160(12):5707-18.
5
DNA vaccines encoding full-length or truncated Neu induce protective immunity against Neu-expressing mammary tumors.编码全长或截短型Neu的DNA疫苗可诱导针对表达Neu的乳腺肿瘤的保护性免疫。
Cancer Res. 1998 May 1;58(9):1965-71.
6
Inhibitory effect of lipopolysaccharide on immune response after DNA immunization is route dependent.脂多糖对DNA免疫后免疫反应的抑制作用具有途径依赖性。
DNA Cell Biol. 1998 Apr;17(4):343-8. doi: 10.1089/dna.1998.17.343.
7
Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara.通过用改良安卡拉痘苗病毒加强免疫增强疟疾DNA疫苗诱导CD8+ T细胞的免疫原性及完全保护效力。
Nat Med. 1998 Apr;4(4):397-402. doi: 10.1038/nm0498-397.
8
Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction.对编码靶向免疫诱导部位的融合抗原的DNA疫苗的反应增强。
Nature. 1998 Mar 26;392(6674):408-11. doi: 10.1038/32932.
9
Influence of cellular location of expressed antigen on the efficacy of DNA vaccination: cytotoxic T lymphocyte and antibody responses are suboptimal when antigen is cytoplasmic after intramuscular DNA immunization.表达抗原的细胞定位对DNA疫苗接种效果的影响：肌内DNA免疫后，当抗原位于细胞质中时，细胞毒性T淋巴细胞和抗体反应不理想。
Int Immunol. 1997 Dec;9(12):1897-906. doi: 10.1093/intimm/9.12.1897.
10
Induction by DNA immunization of a protective antitumor cytotoxic T lymphocyte response against a minimal-epitope-expressing tumor.通过DNA免疫诱导针对表达最小表位的肿瘤的保护性抗肿瘤细胞毒性T淋巴细胞反应。
Cancer Immunol Immunother. 1998 Jan;45(5):273-9. doi: 10.1007/s002620050443.