Han A, Xiong M, Zong Y
Department of Pathology, Sun Yat-Sen University of Medical Sciences, Guangzhou.
Zhonghua Bing Li Xue Za Zhi. 1997 Aug;26(4):222-4.
To study the relationship between pulmonary lymphoepithelima-like carcinoma (LELC) and Epstein-Barr virus (EBV).
30 cases of LELC and 19 cases of non LELC pulmonary pulmonary specimens were studied by in situ hybridization and immunohistochemistry techniques to detect EB virus small RNA (EBERs), latent menbrane protein-1 (LMP-1) and virus capsid antigen (VCA).
The detection rates for EBER, LMP-1 and VCA were 93.3% (28/30), 53.3% (16/30) and 23.3% (7/30) respectively. LMP-1 positive carcinoma cells were not found in the 19 non-LELC specimens, which were used as the controls.
Pulmonary LELC is closely associated with latent EBV infection and may be an important factor involved in the development and progression of LELC. In addition, EBV lytic gene products may sometimes be found in a small portion of LELC cells.
研究肺淋巴上皮瘤样癌（LELC）与爱泼斯坦-巴尔病毒（EBV）之间的关系。
采用原位杂交和免疫组化技术，对30例LELC肺组织标本和19例非LELC肺组织标本进行研究，检测EB病毒小RNA（EBERs）、潜伏膜蛋白-1（LMP-1）和病毒衣壳抗原（VCA）。
EBER、LMP-1和VCA的检出率分别为93.3%（28/30）、53.3%（16/30）和23.3%（7/30）。19例作为对照的非LELC标本中未发现LMP-1阳性癌细胞。
肺LELC与EBV潜伏感染密切相关，可能是LELC发生发展的重要因素。此外，在一小部分LELC细胞中有时可发现EBV裂解基因产物。
