8-（N，N-二乙氨基）-正辛基-3,4,5-三甲氧基苯甲酸酯对培养的血管平滑肌细胞钙动力学的作用
8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate actions on calcium dynamics in cultured vascular smooth muscle cells.
作者信息
Liu S X, Chiou G C, Chen Z
机构信息
Department of Medical Pharmacology and Toxicology, Texas A & M University College of Medicine, College Station 77843-1114, USA.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):21-4.
AIM
To study 8-(N,N-Diethylamino)n-octyl-3,4,5-trimethoxybenzoate (TMB), a potent Ca(2+)-antagonist, actions on cellular calcium dynamics in vascular smooth muscle cell (VSMC) cultures.
METHODS
A7r5 VSMC were cultured with Fura-2 measurements of intracellular Ca2+ concentration, [Ca2+]i.
RESULTS
TMB reduced [Ca2+]i from control levels and blocked [Ca2+]i increase caused by norepinephrine (NE) and 2,5-di (t-butyl)-1,4-benzohydroquinone (BHQ). [Ca2+]i reduction by TMB was further enhanced by ryanodine.
CONCLUSION
TMB is an effective agent for blocking the [Ca2+]i increase caused by NE and BHQ and for enhancing the [Ca2+]i reduction caused by ryanodine.
目的
研究强效钙（Ca²⁺）拮抗剂8 - （N，N - 二乙氨基）正辛基 - 3,4,5 - 三甲氧基苯甲酸酯（TMB）对血管平滑肌细胞（VSMC）培养物中细胞钙动力学的作用。
方法
培养A7r5血管平滑肌细胞，用Fura - 2测量细胞内钙离子浓度[Ca²⁺]i。
结果
TMB使[Ca²⁺]i从对照水平降低，并阻断去甲肾上腺素（NE）和2,5 - 二（叔丁基）- 1,4 - 苯二酚（BHQ）引起的[Ca²⁺]i升高。TMB引起的[Ca²⁺]i降低被兰尼碱进一步增强。
结论
TMB是一种有效药物，可阻断NE和BHQ引起的[Ca²⁺]i升高，并增强兰尼碱引起的[Ca²⁺]i降低。
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