蝙蝠葛碱、奎尼丁和索他洛尔对体外乳头肌动作电位时程的影响。
Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro.
作者信息
Guo D L, Zeng F D, Hu C J
机构信息
Institute of Clinical Pharmacology, Tongji Medical University, Wuhan, China.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Jul;18(4):348-50.
AIM
To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD).
METHODS
Using intracellular microelectrode method to record APD in guinea pig papillary muscles.
RESULTS
Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence.
CONCLUSION
[corrected] The effect of dauricine on APD depends on activation frequency.
目的
比较蝙蝠葛碱、索他洛尔和奎尼丁对动作电位时程（APD）的影响特征。
方法
采用细胞内微电极法记录豚鼠乳头肌的动作电位时程。
结果
20μmol.L-1的蝙蝠葛碱可延长动作电位复极化90%时的时程，在200 - 2000ms的心动周期长度下，动作电位时程延长的百分比分别为22±8、11±6、9±5、7±5、6±3、4.3±2.8、4.5±2.8，蝙蝠葛碱在短心动周期长度时延长动作电位时程的效果更明显。蝙蝠葛碱延长动作电位时程的作用表现为正常使用依赖性，而1μmol.L-1的奎尼丁和10μmol.L-1的索他洛尔在短心动周期长度时延长动作电位时程的效果较差。奎尼丁和索他洛尔对动作电位时程的作用表现为反向使用依赖性。
结论
蝙蝠葛碱对动作电位时程的影响取决于激活频率。
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