Guo D L, Zeng F D, Hu C J
Institute of Clinical Pharmacology, Tongji Medical University, Wuhan, China.
Zhongguo Yao Li Xue Bao. 1997 Jul;18(4):348-50.
To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD).
Using intracellular microelectrode method to record APD in guinea pig papillary muscles.
Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence.
[corrected] The effect of dauricine on APD depends on activation frequency.
比较蝙蝠葛碱、索他洛尔和奎尼丁对动作电位时程（APD）的影响特征。
采用细胞内微电极法记录豚鼠乳头肌的动作电位时程。
20μmol.L-1的蝙蝠葛碱可延长动作电位复极化90%时的时程，在200 - 2000ms的心动周期长度下，动作电位时程延长的百分比分别为22±8、11±6、9±5、7±5、6±3、4.3±2.8、4.5±2.8，蝙蝠葛碱在短心动周期长度时延长动作电位时程的效果更明显。蝙蝠葛碱延长动作电位时程的作用表现为正常使用依赖性，而1μmol.L-1的奎尼丁和10μmol.L-1的索他洛尔在短心动周期长度时延长动作电位时程的效果较差。奎尼丁和索他洛尔对动作电位时程的作用表现为反向使用依赖性。
蝙蝠葛碱对动作电位时程的影响取决于激活频率。
