Zhu J Q, Zeng F D, Hu C J
Department of Clinical Pharmacology, Tongji Medical University, Hankou, China.
Zhongguo Yao Li Xue Bao. 1990 Nov;11(6):506-9.
Dauricine (Dau) 1-30 mumol/L produced the concentration-dependent depression of APA, Vmax, MDP, and RP, and prolongations of APD90 of Purkinje fibers (PF) and epicardial ventricular muscles (VM) from both infarcted and non-infarcted zones. The ERP was lengthened only in non-ischemic PF and VM, and APD50 in non-ischemic PF, non- and ischemic VM. The prolonging effects of Dau on APD and ERP of ischemic PF were much less than those of non-ischemic ones, and its depressing effect on the Vmax of ischemic VM was markedly greater than that of non-ischemic VM. The results suggest that Dau exerts its anti-arrhythmic effect through further depressing conduction of ischemic zone.
蝙蝠葛碱（Dau）1 - 30 μmol/L可使浦肯野纤维（PF）以及梗死和非梗死区的心外膜心室肌（VM）的动作电位幅度（APA）、最大上升速率（Vmax）、最大舒张电位（MDP）和静息电位（RP）呈浓度依赖性降低，并使APD90延长。有效不应期（ERP）仅在非缺血性PF和VM中延长，APD50在非缺血性PF以及非缺血和缺血性VM中延长。Dau对缺血性PF的动作电位时程（APD）和ERP的延长作用远小于对非缺血性PF的作用，而其对缺血性VM的Vmax的抑制作用明显大于对非缺血性VM的作用。结果表明，Dau通过进一步抑制缺血区的传导发挥抗心律失常作用。
