Effect of saponins of Panax notoginseng on synaptosomal 45Ca uptake.
作者信息
Ma L Y, Xiao P G, Liang F Q, Chi M G, Dong S J
机构信息
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, China.
出版信息
Zhongguo Yao Li Xue Bao. 1997 May;18(3):213-5.
AIM
To explore the calcium uptake antagonism of saponins of Panax notoginseng (PNS).
METHODS
Synaptosomes were prepared from rat cerebral cortex by using differential Ficoll gradients. The effects of PNS on synaptosomal 45Ca uptake were measured in vitro or after acute treatment.
RESULTS
PNS 50-800 mg.L-1 produced a concentration-rated inhibition of Ca2+ uptake [IC50 = 111 (46-176) mg.L-1]. Both initial and maximal uptake were inhibited. Similar effect was obtained after acute PNS treatment with 200 mg.kg-1 i.p. The blocking effect of PNS was reversed by calcium in media.
CONCLUSION
PNS is a calcium channel blocker in neurons.
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