三七总皂苷对自发性高血压大鼠心肌细胞内钙离子及肌浆网膜钙泵活性的影响
[Effect of total saponins of Panax notoginseng (TSPNS) on myocardial intracellular Ca2+ and activity of calcium pump of membrane of sarcoplasmic reticulum in SHR].
作者信息
Feng P, Jiang H
机构信息
Zhejiang Traditional Chinese Medical College, Affiliated Hospital, Hangzhou 310006.
出版信息
Zhongguo Zhong Yao Za Zhi. 1998 Mar;23(3):173-5, inside backcover.
PMID:11596240
Abstract
A comparative study was conducted on the action of TSPNS, NS and Captopril in treating SHR, with WKY of similar ages taken as normal control. The results demonstrate that TSPNS helps increase the effect of calcium pump on the membrane of sarcoplasmic reticulum, decrease the myocardial intracellular Ca2+ and reduce the mass of the left ventricular muscle.
摘要
对三七总皂苷（TSPNS）、生理盐水（NS）和卡托普利治疗自发性高血压大鼠（SHR）的作用进行了一项对比研究，以年龄相仿的WKY大鼠作为正常对照。结果表明，三七总皂苷有助于增强肌浆网膜上钙泵的作用，降低心肌细胞内钙离子浓度，并减轻左心室重量。
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