丁丙诺啡对海洛因依赖的快速脱毒治疗
Rapid detoxification of heroin dependence by buprenorphine.
作者信息
Liu Z M, Cai Z J, Wang X P, Ge Y, Li C M
机构信息
National Institute on Drug Dependence, Beijing Medical University, China.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Mar;18(2):112-4.
AIM
To evaluate the clinical efficacy of buprenorphine (Bup) in treatment of acute heroin withdrawal.
METHODS
Bup was given sublingually daily to 60 cases of heroin addicts in 3 groups: low, medium, and high doses. Withdrawal signs and symptoms of heroin were rated by Clinical Institute Narcotic Assessment. Craving for heroin during detoxification was assessed by Visual Analogue Scale. The side effects of Bup was assessed by Treatment Emergent Symptom Scale.
RESULTS
The mean daily consumption of Bup in low, medium, and high group was 2.0, 2.9, and 3.6 mg, respectively. Bup not only suppressed objective signs and withdrawal symptoms for heroin withdrawal, but also reduced the duration for heroin detoxification over 7-8 d.
CONCLUSION
Bup is an effective and rapid detoxification agent with fewer side effects for treatment of acute heroin withdrawal.
目的
评估丁丙诺啡（Bup）治疗急性海洛因戒断的临床疗效。
方法
将60例海洛因成瘾者分为3组，分别给予低、中、高剂量的丁丙诺啡舌下含服。采用临床研究所麻醉品评估量表对海洛因戒断症状和体征进行评分。采用视觉模拟量表评估戒毒期间对海洛因的渴求程度。采用治疗中出现的症状量表评估丁丙诺啡的副作用。
结果
低、中、高剂量组丁丙诺啡的日均消耗量分别为2.0、2.9和3.6毫克。丁丙诺啡不仅能抑制海洛因戒断的客观体征和戒断症状，还能缩短7-8天的海洛因戒毒时间。
结论
丁丙诺啡是一种治疗急性海洛因戒断有效、快速且副作用较少的戒毒药物。
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