Blennow G, Fergusson A, Medvedeo A
Universitetssjukhuset MAS, Malmö.
Lakartidningen. 2000 Apr 12;97(15):1830-3.
Buprenorphine might be an alternative drug to be used in opiate detoxification. Its main advantage is that it carries a low risk for respiratory depression, it gives less euphoria and limited withdrawal effects. In a pilot detoxification project ten heroin addicts were given buprenorphine; seven completed the course. Before detoxification seven patients showed five or more signs on the Himmelsbach scale [6]. After the second day four patients showed no signs, four patients displayed one sign, two patients two signs. Buprenorphine may be a valuable alternative to clonidine, dextropropoxiphene and methadone in the detoxification of opiate addicts.
丁丙诺啡可能是用于阿片类药物脱毒的一种替代药物。其主要优点是呼吸抑制风险低,产生的欣快感较少且戒断反应有限。在一个试点脱毒项目中,给10名海洛因成瘾者使用了丁丙诺啡;7人完成了疗程。脱毒前,7名患者在希默尔斯巴赫量表上显示出5个或更多症状[6]。第二天后,4名患者无任何症状,4名患者显示1个症状,2名患者显示2个症状。在阿片类成瘾者的脱毒治疗中,丁丙诺啡可能是可乐定、右丙氧芬和美沙酮的一种有价值的替代药物。