Liu J, Cheng J S
National Laboratory of Medical Neurobiology, Department of Neurobiology, Shanghai Medical University, China.
Zhongguo Yao Li Xue Bao. 1997 Mar;18(2):189-91.
To study the effect of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and bicuculline (Bic) on benzyl-penicillin-induced-epilepsy (PIE) and electroacupuncture (EA) antiepilepsy in rats.
Epilepsy was elicited by intra-hippocampal microinjection of benzylpenicillin in rats. The analysis of electroencephalogram (EEG) and power spectrum was used to measure the extent of convulsion.
EA or DNQX (1 microgram) showed partial inhibitory effect on PIE. EA + DNQX caused further inhibition of PIE, and Bic attenuated EA antiepileptic effect.
Antagonization of GABA-A receptor attenuated EA antiepileptic effect, and EA acted synergistically with the antagonists of non-N-methyl-D-aspartate (non-NMDA) receptors.
研究6,7-二硝基喹喔啉-2,3-二酮（DNQX）和荷包牡丹碱（Bic）对大鼠苄基青霉素诱发癫痫（PIE）及电针（EA）抗癫痫作用的影响。
通过向大鼠海马内微量注射苄基青霉素诱发癫痫。采用脑电图（EEG）分析和功率谱测量惊厥程度。
EA或DNQX（1微克）对PIE有部分抑制作用。EA + DNQX进一步抑制PIE，而Bic减弱EA的抗癫痫作用。
γ-氨基丁酸A（GABA-A）受体拮抗剂拮抗作用减弱了EA的抗癫痫作用，且EA与非N-甲基-D-天冬氨酸（非NMDA）受体拮抗剂协同发挥作用。
