Locati M, Murphy P M
Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy.
Annu Rev Med. 1999;50:425-40. doi: 10.1146/annurev.med.50.1.425.
Chemokines constitute a large family of chemotactic cytokines that act at G protein-coupled receptors to regulate diverse biological processes, including leukocyte trafficking, angiogenesis, hematopoiesis, and organogenesis. They are believed to be both beneficial in host defense against infectious agents and harmful in diseases marked by pathologic inflammation; however, actual clinical roles in these areas have not yet been established. Recently, unexpected ways have been discovered in which medically important pathogens, including HIV-1, exploit or subvert the chemokine system. These and other recent results suggest that targeting specific chemokines and chemokine receptors may have therapeutic utility in both inflammation and infectious disease.
趋化因子构成了一个庞大的趋化性细胞因子家族，它们作用于G蛋白偶联受体，以调节多种生物学过程，包括白细胞迁移、血管生成、造血作用和器官发生。人们认为它们在宿主抵御病原体感染方面有益，但在以病理性炎症为特征的疾病中有害；然而，它们在这些领域的实际临床作用尚未确立。最近，人们发现了包括HIV-1在内的医学上重要的病原体利用或破坏趋化因子系统的意外方式。这些以及其他近期研究结果表明，针对特定趋化因子和趋化因子受体可能在炎症和传染病治疗中具有实用价值。
