Natofsky J G, Lense J, Mayer J C, Yeko T R
Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33606, USA.
Clin Obstet Gynecol. 1999 Mar;42(1):39-47; quiz 55-6. doi: 10.1097/00003081-199903000-00008.
Preliminary studies have demonstrated that salpingocentesis is a safe and effective treatment for unruptured ectopic pregnancies that are visible by transvaginal ultrasound. So far, experience with this technique has been confined to only a few centers around the world. The most promising results of these studies has been the virtual absence of side effects associated with local injection of either methotrexate or hyperosmolar glucose. Large prospective trials comparing efficacy, safety, and overall cost of salpingocentesis against systemic methotrexate will be necessary to better define the role of salpingocentesis in the management of ectopic pregnancy. Patient recruitment for this type of clinical trial would be feasible and acceptable to patients because both treatment arms would avoid surgery.
初步研究表明，输卵管穿刺术是一种安全有效的治疗方法，适用于经阴道超声可见的未破裂异位妊娠。到目前为止，这项技术的经验仅局限于世界上少数几个中心。这些研究最有前景的结果是，局部注射甲氨蝶呤或高渗葡萄糖几乎没有副作用。有必要进行大型前瞻性试验，比较输卵管穿刺术与全身应用甲氨蝶呤的疗效、安全性和总体成本，以便更好地确定输卵管穿刺术在异位妊娠管理中的作用。由于两种治疗方法都无需手术，因此招募此类临床试验的患者是可行的，患者也会接受。
