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Sackler Institute of Pulmonary Pharmacology, King's College London, England.
J Clin Pharmacol. 1999 Mar;39(3):237-40.
The use of theophylline for the treatment of asthma for 45 of the past 50 years has been for its ability to dilate bronchi. The problem has been that at the most effective bronchodilating dose, toxicity was too close for comfort. In the past 5 years, there has been resurgence in theophylline use at lower doses because of some well-documented anti-inflammatory and steroid sparing effects.
在过去50年中的45年里，使用茶碱治疗哮喘一直是利用其扩张支气管的能力。问题在于，在最有效的支气管扩张剂量下，毒性也已近在咫尺，令人不安。在过去5年中，由于一些有充分文献记载的抗炎和节省类固醇作用，低剂量茶碱的使用有所复苏。
