Roy A, Nielsen D, Rylander G, Sarchiapone M, Segal N
Department of Psychiatry at New Jersey VA Healthcare Systems, East Orange Campus, 07018, USA.
J Clin Psychiatry. 1999;60 Suppl 2:12-7; discussion 18-20, 113-6.
Evidence is mounting that genetic factors may be included in the many determinants of suicide. Clinical studies of psychiatric patients have suggested that risk of suicidal behavior is increased by the presence of family history of suicidality, a claim that is also supported by findings of twin and adoption studies. In addition, molecular genetic studies have reported polymorphisms in the tryptophan hydroxylase gene that is involved in the synthesis of serotonin. The genetic susceptibility to suicide, however, tends to affect individuals only in association with stress or psychiatric illness.
越来越多的证据表明，遗传因素可能是自杀的众多决定因素之一。对精神科患者的临床研究表明，有自杀家族史会增加自杀行为的风险，这一说法也得到了双胞胎和收养研究结果的支持。此外，分子遗传学研究报告称，参与血清素合成的色氨酸羟化酶基因存在多态性。然而，自杀的遗传易感性往往仅在与压力或精神疾病相关联时才会影响个体。
