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一例经尸检确诊的早发性阿尔茨海默病患者自杀身亡。

Completed suicide in an autopsy-confirmed case of early onset Alzheimer's disease.

作者信息

Hartzell Jennifer Wiener, Geary Richard, Gyure Kymberly, Chivukula Venkata Ravi, Haut Marc W

机构信息

Department of Supportive Oncology, Levine Cancer Institute, Carolinas HealthCare System, NC 28202, USA.

Department of Neuropsychology & Psychology, Carolinas Rehabilitation, Carolinas HealthCare System, NC 28203, USA.

出版信息

Neurodegener Dis Manag. 2018 Apr;8(2):81-88. doi: 10.2217/nmt-2017-0045. Epub 2018 Jan 10.

DOI:10.2217/nmt-2017-0045
PMID:29319406
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6367712/
Abstract

We report a case of a 57-year-old male with clinically diagnosed and autopsy-confirmed early onset Alzheimer's disease who completed suicide by gunshot wound to the chest. This case has several unique aspects that have not been discussed in previous case reports of completed suicide in Alzheimer's disease. In particular, our patient's death was highly planned with successful compensation for his cognitive deficits. After all firearms had been removed from the home as a safety precaution, he obtained a new weapon, hid it and left himself cues to find and use it. The case is discussed in the context of literature differentiating the neural circuitry propagating impulsive versus planned suicidal acts.

摘要

我们报告一例57岁男性,临床诊断并经尸检证实为早发性阿尔茨海默病,其通过胸部枪伤自杀身亡。该病例有几个独特之处,在先前关于阿尔茨海默病患者自杀身亡的病例报告中尚未讨论过。特别是,我们的患者死亡计划周密,成功弥补了其认知缺陷。作为安全预防措施,家中所有枪支都已被拿走后,他又获取了一把新枪,将其藏起来,并给自己留下寻找和使用它的线索。本文结合区分冲动性自杀行为与计划性自杀行为的神经回路的文献对该病例进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b01c/6367712/4f96c52b06fc/nmt-08-81-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b01c/6367712/1eedd7ad4dbe/nmt-08-81-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b01c/6367712/4f96c52b06fc/nmt-08-81-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b01c/6367712/1eedd7ad4dbe/nmt-08-81-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b01c/6367712/4f96c52b06fc/nmt-08-81-g2.jpg

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本文引用的文献

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Suicide Risk in Alzheimer's Disease: A Systematic Review.阿尔茨海默病中的自杀风险:一项系统综述。
Curr Alzheimer Res. 2016;13(10):1083-99. doi: 10.2174/1567205013666160720112608.
3
Decision-making competence and attempted suicide.决策能力与自杀未遂。
J Clin Psychiatry. 2015 Dec;76(12):e1590-7. doi: 10.4088/JCP.15m09778.
4
Trajectories of suicidal ideation in depressed older adults undergoing antidepressant treatment.接受抗抑郁治疗的老年抑郁症患者自杀意念的轨迹
J Psychiatr Res. 2016 Feb;73:96-101. doi: 10.1016/j.jpsychires.2015.11.004. Epub 2015 Nov 19.
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Paralimbic and lateral prefrontal encoding of reward value during intertemporal choice in attempted suicide.自杀未遂者在跨期选择过程中奖励价值的边缘旁区和前额叶外侧编码
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