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对采用髓芯减压治疗非创伤性股骨头坏死的髋关节进行生存分析。

Survivorship analysis of hips treated with core decompression for nontraumatic osteonecrosis of the femoral head.

作者信息

Bozic K J, Zurakowski D, Thornhill T S

机构信息

Harvard Combined Orthopaedic Surgery, Harvard Medical School, Boston, Massachusetts 02114, USA.

出版信息

J Bone Joint Surg Am. 1999 Feb;81(2):200-9. doi: 10.2106/00004623-199902000-00007.

Abstract

We reviewed the long-term results of core decompression for the treatment of nontraumatic osteonecrosis of the femoral head, performed in thirty-four patients (fifty-four hips) between January 1, 1981, and June 30, 1995. Twenty patients (59 percent) had bilateral involvement. The mean age of the patients at the time of presentation was thirty-eight years (range, twenty-two to eighty-three years). The presumed risk factors were use of corticosteroids (thirty-seven hips), excessive intake of alcohol (eight hips), and use of adrenocorticotropic hormone for the treatment of multiple sclerosis (two hips); the remaining seven hips had idiopathic osteonecrosis. According to a modification of the classification system of Ficat and Arlet in combination with the system of Steinberg et al., thirteen hips were stage I (normal radiographs) preoperatively; seven, stage IIA sclerotic; sixteen, stage IIA cystic or sclerocystic; ten, stage IIB (transitional stage, with a crescent sign); and eight, stage III (collapse). The mean duration of follow-up after the core decompression was 120 months (range, twenty-four to 196 months). The result was considered successful if the patient was asymptomatic, with no progression of the disease, and unsuccessful if there was radiographic failure (progression to stage III [collapse]) or clinical failure (the need for a subsequent operation), or both. The Kaplan-Meier product-limit method was used to estimate clinical and radiographic survival. Overall, twenty-six hips (48 percent) had a satisfactory clinical result and twenty (37 percent) survived according to radiographic criteria. Radiographic or clinical failure, or both, were seen in four of the thirteen stage-I hips, none of the seven stage-IIA sclerotic hips, thirteen of the sixteen stage-IIA cystic or sclerocystic hips, nine of the ten stage-IIB hips, and all eight stage-III hips. On the basis of the Cox proportional-hazards regression model, significant predictors of overall failure included an advanced preoperative radiographic stage (p < 0.0001), a shorter duration of symptoms (p < 0.05), and use of corticosteroids (p < 0.05). No association was found between age, gender, excessive intake of alcohol, or renal transplantation and the overall outcome. Two patients (two hips; 4 percent) had a postoperative complication. One patient had a fracture of the femoral neck, and the other had a hematoma. Our findings suggest that core decompression is a safe and effective procedure for the treatment of stage-I or stage-IIA sclerotic disease. These data also demonstrate the importance of differentiating between stage-IIA sclerotic disease and stage-IIA cystic or sclerocystic disease. We believe that core decompression has a limited role in the operative management of patients who have evidence of cystic changes in the femoral head on plain radiographs.

摘要

我们回顾了1981年1月1日至1995年6月30日期间对34例患者(54髋)进行的非创伤性股骨头坏死髓芯减压术的长期结果。20例患者(59%)为双侧受累。患者就诊时的平均年龄为38岁(范围为22至83岁)。推测的危险因素包括使用皮质类固醇(37髋)、过量饮酒(8髋)以及使用促肾上腺皮质激素治疗多发性硬化症(2髋);其余7髋为特发性骨坏死。根据对Ficat和Arlet分类系统的改良并结合Steinberg等人的系统,术前13髋为I期(X线片正常);7髋为IIA期硬化型;16髋为IIA期囊性或硬化囊性;10髋为IIB期(过渡阶段,有新月征);8髋为III期(塌陷)。髓芯减压术后的平均随访时间为120个月(范围为24至196个月)。如果患者无症状且疾病无进展,则结果被认为成功;如果出现X线片失败(进展至III期[塌陷])或临床失败(需要后续手术),或两者皆有,则结果被认为失败。采用Kaplan-Meier乘积限界法估计临床和X线片生存率。总体而言,26髋(48%)临床结果满意,20髋(37%)根据X线片标准存活。13例I期髋中有4例出现X线片或临床失败,或两者皆有;7例IIA期硬化型髋均未出现;16例IIA期囊性或硬化囊性髋中有13例;10例IIB期髋中有9例;所有8例III期髋均出现。根据Cox比例风险回归模型,总体失败的显著预测因素包括术前X线片分期较晚(p < 0.0001)、症状持续时间较短(p < 0.05)以及使用皮质类固醇(p < 0.05)。未发现年龄、性别、过量饮酒或肾移植与总体结果之间存在关联。2例患者(2髋;4%)出现术后并发症。1例患者发生股骨颈骨折,另1例出现血肿。我们的研究结果表明,髓芯减压术是治疗I期或IIA期硬化型疾病的一种安全有效的方法。这些数据还证明了区分IIA期硬化型疾病和IIA期囊性或硬化囊性疾病的重要性。我们认为,对于X线平片显示股骨头有囊性改变的患者,髓芯减压术在手术治疗中的作用有限。

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