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股骨头缺血性坏死——印度次大陆队列中的人口统计学特征、无症状髋关节的自然病史及天然髋关节生存率

Avascular necrosis of femoral head - Demographic profile, natural history of asymptomatic hips and native hip survivorship in an indian subcontinent cohort.

作者信息

Dorai Jeremy Bliss, Bahadur Bhim, Shankar Arun, Oommen Anil Thomas, Nithyananth Manasseh

机构信息

Department of Orthopaedics-Unit 1, Christian Medical College, Vellore, Tamil Nadu, 632004, India.

Department of Orthopaedics-Unit 3, Christian Medical College, Vellore, Tamil Nadu, 632004, India.

出版信息

J Clin Orthop Trauma. 2024 Nov 10;59:102801. doi: 10.1016/j.jcot.2024.102801. eCollection 2024 Dec.

DOI:10.1016/j.jcot.2024.102801
PMID:39654824
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11625370/
Abstract

BACKGROUND

Avascular Necrosis of the femoral head is still considered an unsolved orthopedic problem despite significant research and advances in treatment.

PURPOSES

1.Describe the demographic pattern2.Assess postoperative survival of the native hip3.Observe the natural history in asymptomatic hips.

PATIENTS AND METHODS

A South Indian quaternary care hospital based retrospective study. Patients diagnosed with non-traumatic avascular necrosis of the femoral head who underwent hip-preserving procedures between 2004 and 2017 were studied. The clinical and radiological outcomes were assessed. Statistical analysis for hip survival was done using Kaplan-Meier survival analysis.

RESULTS

The study was conducted on 306 hips of 190 patients. The most common etiology was steroid intake. The average follow-up period was 8 years. 216(76 %) hips survived clinically and 125(44 %) hips survived radiologically. The mean duration of clinical survival was 8 years and radiological survival was 7.5 years. The overall regression was highest in the fibula grafting. In asymptomatic hips clinical failure was observed in 36(53 %) hips and radiological failure in 52(77 %) hips with a mean follow-up of 5.9 years.

CONCLUSION

The earlier stage of presentation and a hip-preserving surgery exhibited a 70 % chance of survival of the native hip. Core decompression decreased the rate of progression in the early stages. Disease regression rates were significant in fibula grafting for stages 2a and 2b. Non-operative treatment is not advisable given rapid disease progression.

摘要

背景

尽管在股骨头缺血性坏死的治疗方面有大量研究和进展,但它仍然被认为是一个尚未解决的骨科问题。

目的

1.描述人口统计学模式;2.评估患侧髋关节的术后生存率;3.观察无症状髋关节的自然病程。

患者与方法

一项基于南印度四级医疗保健医院的回顾性研究。对2004年至2017年间接受保髋手术的非创伤性股骨头缺血性坏死患者进行研究。评估临床和放射学结果。使用Kaplan-Meier生存分析对髋关节生存率进行统计分析。

结果

该研究纳入了190例患者的306个髋关节。最常见的病因是服用类固醇。平均随访期为8年。216个(76%)髋关节临床存活,125个(44%)髋关节放射学存活。临床存活的平均持续时间为8年,放射学存活为7.5年。腓骨移植的总体退变率最高。在无症状髋关节中,平均随访5.9年,36个(53%)髋关节出现临床失败,52个(77%)髋关节出现放射学失败。

结论

疾病早期表现以及保髋手术使患侧髋关节有70%的存活机会。髓芯减压在早期可降低疾病进展率。对于2a期和2b期,腓骨移植的疾病退变率显著。鉴于疾病进展迅速,不建议采用非手术治疗。

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