新生儿与其母亲尿中6β-羟基皮质醇/皮质醇比值的比较。
Comparison of urinary 6beta-hydroxycortisol/cortisol ratio between neonates and their mothers.
作者信息
Nakamura H, Hasegawa A, Kimura M, Yamagata S, Nakasa H, Osada H, Sekiya S, Ohmori S, Kitada M
机构信息
Division of Pharmacy, Chiba University Hospital, Japan.
出版信息
Br J Clin Pharmacol. 1999 Jan;47(1):31-4. doi: 10.1046/j.1365-2125.1999.00857.x.
AIMS
To assess CYP3A enzyme activity in human neonates by measuring the urinary 6beta-hydroxycortisol/cortisol (6beta-OHF/C) ratio.
METHODS
Fifty-six mature male neonates with normal delivery, seventeen of their mothers and twenty-four healthy non-pregnant young women participated in this study. Urinary 6beta-OHF/C ratio was determined on the day of birth in neonates and their mothers. In addition, changes in the ratio after birth were determined in neonates.
RESULTS
On the day of birth, the urinary 6beta-OHF/C ratio of neonates was significantly higher than that of their mothers (20.5 vs 6.9). In contrast, no significant difference was observed in the mean ratio of urinary 6beta-OHF/C between women with and without pregnancy (6.9 vs 9.0). The urinary 6beta-OHF/C ratio after birth was decreased day by day in neonates.
CONCLUSION
These results indicate that the high urinary 6beta-OHF/C ratio in mature neonates on the day of birth is independent of the activity of CYP3A enzyme in their mothers.
目的
通过测量尿中6β-羟基皮质醇/皮质醇（6β-OHF/C）比值来评估人类新生儿的CYP3A酶活性。
方法
56例正常分娩的成熟男性新生儿、其中17例新生儿的母亲以及24名健康未孕年轻女性参与了本研究。在新生儿及其母亲出生当天测定尿6β-OHF/C比值。此外，还测定了新生儿出生后该比值的变化。
结果
出生当天，新生儿尿6β-OHF/C比值显著高于其母亲（20.5对6.9）。相比之下，怀孕和未怀孕女性尿6β-OHF/C平均比值无显著差异（6.9对9.0）。新生儿出生后尿6β-OHF/C比值逐日下降。
结论
这些结果表明，成熟新生儿出生当天尿6β-OHF/C比值较高与母亲CYP3A酶活性无关。
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