Nee R, Doppenschmidt D, Donovan D J, Andrews T C
Wilford Hall Medical Center, San Antonio, Texas, USA.
Am J Cardiol. 1999 Jan 15;83(2):286-8, A6-7. doi: 10.1016/s0002-9149(98)00842-x.
Our data suggest that compared with the subcutaneous route of administration, intravenous vitamin K1 results in a more prompt reduction in the international normalized ration. However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.
我们的数据表明，与皮下给药途径相比，静脉注射维生素K1能使国际标准化比值更快降低。然而，对于大多数患者而言，皮下注射维生素K1与调整后续华法林剂量联合使用时是一种有效且安全的替代方法，因为实际上所有患者通过这种给药途径在72小时内都达到了安全的抗凝水平。
