Stone Joshua A, Willey Joshua Z, Keyrouz Salah, Butera James, McTaggart Ryan A, Cutting Shawna, Silver Brian, Thompson Bradford, Furie Karen L, Yaghi Shadi
Department of Neurology, The Warren Alpert Medical School of Brown University, 353 Eddy Street APC 530, Providence, RI, 02903, USA.
Departments of Neurology, Columbia University Medical Center, New York, NY, USA.
Curr Treat Options Neurol. 2017 Jan;19(1):1. doi: 10.1007/s11940-017-0438-5.
Hemorrhagic transformation occurs in about 10-15% of patients with acute ischemic stroke. The treatment of hemorrhagic conversion is complex and includes blood pressure management, reversing coagulopathy, and managing its complications including increased intracranial pressure. Future research should be directed on identifying indications to treat and use of appropriate homeostatic regimens to effectively reverse the different anticoagulants and thrombolytic agents in an attempt to improve outcomes of patients with hemorrhagic transformation.
出血性转化发生在约10%-15%的急性缺血性中风患者中。出血性转化的治疗很复杂，包括血压管理、纠正凝血病以及处理其并发症，包括颅内压升高。未来的研究应致力于确定治疗指征，并使用适当的内稳态方案，以有效逆转不同的抗凝剂和溶栓剂，试图改善出血性转化患者的预后。
