霍乱弧菌的极性鞭毛马达由钠离子动力驱动。
The polar flagellar motor of Vibrio cholerae is driven by an Na+ motive force.
作者信息
Kojima S, Yamamoto K, Kawagishi I, Homma M
机构信息
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.
出版信息
J Bacteriol. 1999 Mar;181(6):1927-30. doi: 10.1128/JB.181.6.1927-1930.1999.
Abstract
Vibrio cholerae is a highly motile bacterium which possesses a single polar flagellum as a locomotion organelle. Motility is thought to be an important factor for the virulence of V. cholerae. The genome sequencing project of this organism is in progress, and the genes that are highly homologous to the essential genes of the Na+-driven polar flagellar motor of Vibrio alginolyticus were found in the genome database of V. cholerae. The energy source of its flagellar motor was investigated. We examined the Na+ dependence and the sensitivity to the Na+ motor-specific inhibitor of the motility of the V. cholerae strains and present the evidence that the polar flagellar motor of V. cholerae is driven by an Na+ motive force.
摘要
霍乱弧菌是一种高度可运动的细菌，它拥有一根单一的极鞭毛作为运动细胞器。运动性被认为是霍乱弧菌毒力的一个重要因素。该生物体的基因组测序项目正在进行中，并且在霍乱弧菌的基因组数据库中发现了与溶藻弧菌的Na⁺驱动的极鞭毛马达的必需基因高度同源的基因。对其鞭毛马达的能量来源进行了研究。我们检测了霍乱弧菌菌株运动性对Na⁺的依赖性以及对Na⁺马达特异性抑制剂的敏感性，并提供了证据表明霍乱弧菌的极鞭毛马达由Na⁺动力驱动。
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