骨髓中不同的人类免疫缺陷病毒株与血小板减少症的发生有关。
Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia.
作者信息
Voulgaropoulou F, Tan B, Soares M, Hahn B, Ratner L
机构信息
Departments of Medicine, Washington University, St. Louis, Missouri 63110, USA.
出版信息
J Virol. 1999 Apr;73(4):3497-504. doi: 10.1128/JVI.73.4.3497-3504.1999.
Abstract
We analyzed bone marrow and blood from human immunodeficiency virus type 1 (HIV-1)-infected individuals and described the HIV-1 quasispecies in these cellular compartments. HIV-1 isolates from the bone marrow of thrombocytopenic patients contained distinct amino acids in the V3 loop and infected T-cell lines, implicating this virus in the development of thrombocytopenia.
摘要
我们分析了来自人类免疫缺陷病毒1型（HIV-1）感染个体的骨髓和血液，并描述了这些细胞区室中的HIV-1准种。血小板减少症患者骨髓中的HIV-1分离株在V3环中含有独特的氨基酸，并能感染T细胞系，提示这种病毒与血小板减少症的发生有关。
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