Messiaen T, M'bappé P, Boffa J J, Khayat R, Mougenot B, Rossert J, Ronco P
Department of Nephrology, Tenon Hospital, Paris, France.
Am J Kidney Dis. 1998 Nov;32(5):E6. doi: 10.1016/s0272-6386(98)70153-2.
Two patients with rheumatoid arthritis (RA) developed necrotizing crescentic glomerulonephritis with high titers of anti-myeloperoxidase antibodies (MPO) in the absence of overt extrarenal vasculitis. We therefore suggest that in some patients with RA, MPO-ANCA necrotizing glomerulonephritis (GN) may occur as a kidney-limited form of rheumatoid vasculitis, and that RA should be added to the list of diseases potentially associated with necrotizing GN with anti-MPO antibodies. These observations also point out the importance of repeatedly evaluating titers of anti-MPO antibodies in the course of RA, especially if renal impairment or abnormal urinary sediment are present.
两名类风湿关节炎（RA）患者在无明显肾外血管炎的情况下，出现了伴有高滴度抗髓过氧化物酶抗体（MPO）的坏死性新月体性肾小球肾炎。因此，我们认为在某些RA患者中，MPO-ANCA坏死性肾小球肾炎（GN）可能以类风湿性血管炎的肾脏局限性形式出现，并且RA应被添加到可能与抗MPO抗体相关的坏死性GN的疾病列表中。这些观察结果还指出了在RA病程中反复评估抗MPO抗体滴度的重要性，特别是在存在肾功能损害或尿沉渣异常的情况下。
