Thibonnier M, Berti-Mattera L N, Dulin N, Conarty D M, Mattera R
Department of Medicine, Case Western Reserve University, School of Medicine, Cleveland, OH 44106-4951, USA.
Prog Brain Res. 1998;119:147-61. doi: 10.1016/s0079-6123(08)61568-x.
Vasopressin (VP) and oxytocin (OT) are cyclic nonapeptides whose actions are mediated by stimulation of specific G protein-coupled receptors (GPCRs) currently classified into V1-vascular (V1R), V2-renal (V2R) and V3-pituitary (V3R) VP receptors and OT receptors (OTR). The recent cloning of the different members of the VP/OT family of receptors now allows the extensive characterization of the molecular determinants involved in ligand binding and signal transduction pathways coupled to a given VP/OT receptor subtype in stably transfected mammalian cell lines. In this article, we review the present knowledge of the signal transduction pathways coupled to the different VP/OT receptor subtypes and we present new observations derived from the study of each human VP or OT receptor subtype stably expressed in CHO cells.
血管加压素（VP）和催产素（OT）是环状九肽，其作用通过刺激特定的G蛋白偶联受体（GPCRs）介导，这些受体目前分为V1-血管（V1R）、V2-肾（V2R）和V3-垂体（V3R）VP受体以及OT受体（OTR）。最近对VP/OT受体家族不同成员的克隆，现在使得能够在稳定转染的哺乳动物细胞系中广泛表征参与配体结合和与给定VP/OT受体亚型偶联的信号转导途径的分子决定因素。在本文中，我们综述了与不同VP/OT受体亚型偶联的信号转导途径的现有知识，并展示了对在CHO细胞中稳定表达的每个人类VP或OT受体亚型研究得出的新观察结果。
